A retrospective study of local relapse after high grade osteosarcoma

Aim of this study is to analyse the modalities of diagnosis of LR in high-grade osteosarcoma, pattern of recurrence, treatment of LR and factors influencing post-LR survival (PLRS) focusing on the role of second line chemotherapy, margins and type of surgery


Contact
Emanuela Palmerini, Bologna
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pdfSynopsis OSTEO LR.pdf613.67 KB

xlsLR osteo database JUNE 19.xls23.00 KB

EMSOS+EPOS boncyste retrospective cohort collaborative study

Unicameral bone cysts (UBC), also called simple bone cysts, Aneurysmal bone cysts (ABC) (and Fibrous Dysplasia (FD) lesions) can present as benign fluid filled cavities that can enlarge over time, leading to thinning and with that weakening of the bone. Both bone cysts and FD predominantly occur in children and adolescents, with a peak age between 3 and 14 years [1-3]. The annual prevalence and incidence are both estimated at ±0.3 per 100.000 people for UBC [4, 5]. For ABC, the annual prevalence is estimated at ±0.3, with an annual incidence ranging from 0.14 to 0.54 per 100.000 people [1, 4-6]. However, the true prevalence and incidence is difficult to estimate due to clinically silent cases and spontaneous regression. For the same reason the incidence and prevalence of FD is unknown and no estimation is given in literature.


Contact
Michiel van de Sande (Leiden)
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pdfResearchprotocol bone cysts EPOS anf EMOS May 27 2019.pdf569.87 KB

pdfAbbreviatures excel database 14-05-2019.pdf118.35 KB

xlsDatabase Bonecysts.xls69.5 KB

zipDatabase Bonecysts SPSS.zip4.42 KB

PROJECT: Tumors at the elbow –
clinical and oncological results  
after resection and endoprosthesis replacement 

Invitation to participate the study

Dear colleagues,  hereby we invite you to participate in a multicentric retrospective study “Tumors at the elbow – 
clinical and oncological results after resection and endoprosthesis replacement”. 

Bone and soft tissue tumors involving the elbow are very rare. There is a limited knowledge about 
clinical and oncological results of distal humerus and/or proximal ulna resection and endoprosthetic elbow 
reconstruction: in the last two decades only a few publications analyzed this problem, including per study 
at average about 20 patients. These studies include numerous various parameters (different implants, 
various diagnosis…), making the task of summarizing the results not easy.  


Contact
Dr. Marko Bergovec  
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pdfElbow TM-invitation.pdf141.66 K

pdfElbow TM-protocol and scores.pdf276.15 KB

xlsElbow TM-data.xls76.00 KB

EMSOS study “Sarcoma during Pregnancy”

Malignancy during pregnancy is a very rare entity with an estimated incidence of 1/1000 pregnancies.
Individual therapeutic customization is the only choice of treatment with respect to the health of the
mother, and her child.

The occurrence of sarcoma during pregnancy is even more exceptional, with about 140 reported cases
in the accessible literature. 60% is reported as primary soft tissue sarcomas, 40% as primary bone
sarcomas. No true systematic study has been undertaken to investigate the whole diagnostic,
therapeutic and prognostic concept of these sarcomas during pregnancy as an ‘entity’.


Contact
University Department of Experimental Pathology, Vrije Universiteit Brussel, Belgium.
Prof. dr. Ramses Forsyth, director (This email address is being protected from spambots. You need JavaScript enabled to view it.).

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pdfEMSOS study Sarcoma during Pregnancy.pdf136.25 KB

xlsEMSOS study Sarcoma during Pregnancy.xls38.50 KB

Expandable distal femoral megaprostheses

Over the last 20 years, expandable prostheses have made a significant impact on the reconstruction methods we routinely use in children with bone tumors.[1-4] Although these implants are expensive and associated with a high complication rate [5-9], even in experienced hands, they are considered the main reconstructive option for children in a certain age group and for selected bone segments.

Contact
Eric Staals
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Musculoskeletal Oncology Department
Istituto Ortopedico Rizzoli, Bologna, Italy

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pdf
EMSOS study on expandable distal femoral megaprostheses.pdf190.02 KB

xlsData Collection Expandable EMSOS.xls

Desmoplastic Fibroma of bone

Fibroma of bone is a rare, locally aggressive bone tumor. Once it was called the osseous counterpart of extra-abdominal desmoid tumor, because of the histological aspects. In 2013, the WHO described the microscopic appearance of desmoplastic fibroma as being composed of slender, spindle to stellate cells with minimal cytological atypia and abundant collagenous matrix.

Contact
:
Frank Traub MD, PhD | This email address is being protected from spambots. You need JavaScript enabled to view it.
Dimosthenis Andreou, M.D. | This email address is being protected from spambots. You need JavaScript enabled to view it.

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pdfDesmoplastic Fibroma of bone.pdf135.88 KB
xlsDesmoplastic Fibroma EMSOS study datasheet.xls48.00 KB

EMSOS Extra-abdominal Fibromatosis Multicenter Study

Desmoid-type fibromatosis is an intermediate soft tissue tumour (WHO) with clonal fibroblastic proliferation originating in the deep soft tissues. It is characterised by local infiltration without metastatic potential. In the past decades resectable masses have been mainly treated surgically with a high incidence of local recurrence in up to one third of the patients independently from resection margins. Local recurrence negative prognostic factors after surgery have been identified in younger age, female gender, distal limb location and recurrent disease.

Alternative management including radioterapy or medical treatment with NSAIDS, hormone therapy, chemotherapy and tyrosine kinase inhibitors led to high recurrence rate as well.

As a consequence in recent years the wait and see approach, with strict and close clinical and instrumental monitoring of the involved site has gained popularity as first line management for silent masses not involving neurovascular bundles.

Contact: Prof Domenico Andrea Campanacci | This email address is being protected from spambots. You need JavaScript enabled to view it.


Downloads
pdfEMSOS Fibromatosis study.pdf131.83 KB
xlsEMSOS database.xls36.00 KB

Clear cell chondrosarcoma

Clear cell chondrosarcoma is a rare variant of chondrosarcoma, behaving as a low grade malignant bone tumor and characterized by a proliferation of tumor cells with clear cytoplasm.

Clear cell chondrosarcomas account for around 2% of all chondrosarcomas. They have been described in most bones of the body but usually affect the proximal epiphysis of the humerus or femur.

Contact
Doz. Dimosthenis Andreou, Münster, Germany
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Downloads
pdfClear cell chondrosarcoma  EMSOS study 20170906.pdf90.27 KB
xlsClear cell chondrosarcoma EMSOS study protocol.xls36.00 KB

Mazabraud syndrome

Mazabraud Syndrome is a very rare combination of fibrous dysplasia (FD) and intramusculary myxomas. Both entities are caused by activating GNAS-mutations and while FD is often diagnosed at a younger age, myxomas tend to arise later, often in the fourth or fifth decade of life, and are localized adjacent to FD lesions in the majority of the patients. The myxomas can lead to mechanical problems and symptoms of pain. Excision of the myxomas has been proposed, although outcome of surgical interventions and whether there are predictive factors for recurrence of the myxomas remains eluded.

If you need any assistance please contact Bas Majoor,  This email address is being protected from spambots. You need JavaScript enabled to view it.

 

   Case inclusion protocol EMSOS study Mazabraud Syndrome pds.docx14.93 KB
  Mazabraud database multicentre file pds.xls48 KB

 

EMSOS Study "Angiosarcoma"

Angiosarcoma is the malignant end of the spectrum of vascular tumors, spanning diagnosis including hemangiomas, hemangioendothelioma, well-differentiated and poorly-differentiated angiosarcoma.

Angiosarcoma of bone is rare, accounting for <1% of all primary bone sarcomas and it is associated with a poor prognosis. Although any age can be affected, the incidence is highest between 50 and 70 years of age.

Angiosarcoma of bone may present as unifocal or multifocal disease. The most common locations of unifocal tumor are the long and short tubular bones, followed by the pelvis, and trunk.

Histologically, angiosarcomas of bone are composed of anastomosing vascular channels lined by atypical endothelial cells with enlarged nuclei, prominent nucleoli, and increased mitoses. Inflammatory cells, mostly eosinophils, may be present.

Given the rarity of angiosarcoma of bone, the literature is limited regarding treatment and outcome of patients with this tumor.

The role of chemotherapy and prognostic factors for these patients remain unclear.

Under the auspices of the EMSOS, a retrospective  study has been launched with the aim of  improving  our knowledge on the natural history of the tumor and on prognostic and predictive factors of survival.

Contact
Stefano Ferrari MD
SSD Chemioterapia dei Tumori Muscoloscheletrici
Istituto Ortopedico Rizzoli – WWW.ior.it
Via Pupilli 1, 40136 Bologna. Italy
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Bone Angiosarcoma-Legend for Spreadsheet.pdf43.27 KB
Angiosarcoma of Bone Spreadsheet July 2015.xls41 KB

 

DGOOC / EMSOS study "Clear cell sarcoma"

Osteosarcoma after retinoblastoma

Contact
Sebastian Asaftei, Torino / This email address is being protected from spambots. You need JavaScript enabled to view it.

European Relapsed Osteosarcoma Registry "EURELOS"

EURELOS EUropean RELapsed OsteoSarcoma Registry